Metagenics Resist-X Advanced 60 tablets

Metagenics Resist-X Advanced

Size: 60 tablets (30 days)

Metagenics Resist-X Advanced Summary:

• An innovative formula containing berberine and milk thistle which exert a synergistic effect to target insulin resistance and liver dysfunction simultaneously.
• Supports healthy blood sugar balance and carbohydrate metabolism.
• Supports the liver and modulates lipid metabolism.

Metagenics Resist-X Advanced AUST L 389879

Metagenics Resist-X Advanced

• Metgenics Resist-X Advanced contains chromium, which supports healthy blood sugar balance and glucose homeostasis.
• Indian barberry (in traditional Ayurvedic medicine), and milk thistle have been shown to support liver function and together, exert a synergistic effect.
• Indian barberry (in traditional Ayurvedic medicine) assists in the breakdown of dietary fats.
• Chromium in Resist-X Advanced supports carbohydrate metabolism and milk thistle protects healthy cells from oxidative damage via antioxidant activity.

Benefits: Metagenics Resist-X Advanced

Berberine from Indian barberry and milk thistle exert a synergistic effect.1 Milk thistle supports healthy liver function and reduces free radicals formed in the body.2 Berberine typically has low oral bioavailability, and its cellular uptake is limited by the P-glycoprotein efflux pump located on cell membranes. Milk thistle flavonolignans act as inhibitors of this pump,3 supporting berberine’s cellular uptake (Figure 1).4 In a single-blind, randomised placebo-controlled trial, patients with elevated blood sugar given the combination of 210 mg per day of milk thistle flavonolignans with Indian barberry, equating to 1 g per day of berberine, was shown to synergistically increase berberine’s therapeutic effects on glycosylated haemoglobin (HbA1c) compared to the same dose of Indian barberry given alone (p<0.05).5 The two ingredients in a randomised double-blind placebo-controlled trial led to signification reductions in biomarkers: body mass index (BMI), waist circumference and visceral fat compared to placebo after 12 months of supplementation (p<0.01).6

Poor blood sugar control is associated with low-grade systemic inflammation (meta inflammation) caused by nutrient excess.8 The twin-cycle hypothesis presents the interconnecting pathways following overnutrition and inflammation, leading to fat accumulation in the liver and insulin resistance. The result of higher very low-density lipoprotein (VLDL) in the circulation leads to fat accumulation in the pancreas and subsequently, beta cells (β-cells) dysfunction.9 To improve insulin resistance, both pancreatic β islet cell dysfunction and liver lipid metabolism must be addressed (Figure 2).10,11

Chromium assists carbohydrate metabolism, supports healthy blood sugar, and is an essential element in glucose homeostasis.13 It achieves this by promoting insulin signalling.14 A meta-analysis of human clinical trials showed combining milk thistle and Indian barberry presented a significant reduction in fasting blood glucose, total cholesterol, triglycerides, low density lipoproteins, and a significant increase in high-density lipoproteins.15

Metabolic stress, such as lipodysfunction and meta inflammation may predispose to pancreatic impairment.16 Metabolic imbalances (e.g. fatty liver, insulin resistance, weight gain and hormonal imbalances) all involve liver function alterations, fatty acid abnormalities and changes in blood sugar control.17 Berberine aids the breakdown of dietary fat and protects the liver. In an animal study, berberine improves pancreatic β islet cell function under metabolic stress.18 In another animal study, berberine has been shown to reduce hypercaloric induced liver lipid infiltration,19 and was also shown to inhibit pancreatic inflammation and pancreatic β islet cell damage associated with insulin resistance.20

Figure 1: Milk thistle’s Flavanolignans Support Berberine’s Cellular Uptake.7

Figure 2: The Twin Cycle Hypothesis – Addressing the Pancreas and the Liver.12

Ingredients: Metagenics Resist-X Advanced

Each tablet contains:
Chromic chloride hexahydrate	705micrograms
equivalent chromium	138micrograms
Chromium picolinate	101micrograms
equivalent chromium	13micrograms
Dry herbal extracts:
Berberis aristata (Indian Barberry), root	1g
Derived from dry root	5g
Equivalent to berberine chloride	500mg
Silybum marianum (Milk Thistle), seed	125mg
Derived from dry seed	8.8g
equivalent to Flavanolignans calculated as Silybin	105mg